Research Guides: Internal Medicine Residency Readings: Morning Report

Education

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Clinical/EBM

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Contact:

Laura Abate, MSLS
leabate@gwu.edu
202-994-8570

June 15, 2018

ABG vs VBG
Byrne AL, Bennett M, Chatterji R, Symons R, Pace NL, Thomas PS. Peripheral venous and arterial blood gas analysis in adults: are they comparable? A systematic review and meta-analysis. Respirology. 2014 Feb;19(2):168-175. doi: 10.1111/resp.12225. Epub 2014 Jan 3. Review. PubMed PMID: 24383789.
Assessment of Patients' Competence to Consent to Treatment
Appelbaum PS. Clinical practice. Assessment of patients' competence to consent to treatment. N Engl J Med. 2007 Nov 1;357(18):1834-40. Review. PubMed PMID: 17978292.
Decision-Making Capacity
Chapter 10: Decision-Making Capacity from Resolving Ethical Dilemmas: A Guide for Clinicians, 5e
Guardianship: Last Week Tonight with John Oliver (HBO)
Video link

June 13, 2018

Dizziness and vertigo
Wipperman J. Dizziness and vertigo. Prim Care. 2014 Mar;41(1):115-31. doi: 10.1016/j.pop.2013.10.004. Review. PubMed PMID: 24439886.
The Hints Exam (video)
Peter John’s, University of Ottawa
How to perform the Dix-Hallpike & Modified Epley's Maneuver (video)

June 8, 2018

Cystic lung disease
Ha D, Yadav R, Mazzone PJ. Cystic lung disease: systematic, stepwise diagnosis. Cleve Clin J Med. 2015 Feb;82(2):115-27. doi: 10.3949/ccjm.82a.14020. Review. PubMed PMID: 25897602.
Birt-Hogg-Dube Syndrome
Gupta N, Sunwoo BY, Kotloff RM. Birt-Hogg-Dubé Syndrome. Clin Chest Med. 2016 Sep;37(3):475-86. doi: 10.1016/j.ccm.2016.04.010. Epub 2016 Jun 25. Review. PubMed PMID: 27514594.
Lymphangioleiomyomatosis
Johnson SR, Taveira-DaSilva AM, Moss J. Lymphangioleiomyomatosis. Clin Chest Med. 2016 Sep;37(3):389-403. doi: 10.1016/j.ccm.2016.04.002. Review. PubMed PMID: 27514586.

June 6, 2018

Fever of unknown origin
Cunha BA, Lortholary O, Cunha CB. Fever of unknown origin: a clinical approach. Am J Med. 2015 Oct;128(10):1138.e1-1138.e15. doi: 10.1016/j.amjmed.2015.06.001. Epub 2015 Jun 18. Review. PubMed PMID: 26093175.
FUO - rheum causes
Mulders-Manders CM, Simon A, Bleeker-Rovers CP. Rheumatologic diseases as the cause of fever of unknown origin. Best Pract Res Clin Rheumatol. 2016 Oct;30(5):789-801. doi: 10.1016/j.berh.2016.10.005. Epub 2016 Nov 9. Review. PubMed PMID: 27964789.
Still disease
Castañeda S, Blanco R, González-Gay MA. Adult-onset Still's disease: Advances
in the treatment. Best Pract Res Clin Rheumatol. 2016 Apr;30(2):222-238. doi: 10.1016/j.berh.2016.08.003. Epub 2016 Oct 5. Review. PubMed PMID: 27886796.
HLH
Sifers TM, Raje N, Dinakar C. Hemophagocytic lymphohistiocytosis: A concise review for the practicing physician. Allergy Asthma Proc. 2016 May;37(3):256-8. doi: 10.2500/aap.2016.37.3948. Review. PubMed PMID: 27178894.

June 1, 2018

Thrombocytopenia
Stasi R. How to approach thrombocytopenia. Hematology Am Soc Hematol Educ Program. 2012;2012:191-7. doi: 10.1182/asheducation-2012.1.191. Review. PubMed PMID: 23233580.
Thrombocytopenia
Gauer RL, Braun MM. Thrombocytopenia. Am Fam Physician. 2012 Mar 15;85(6):612-22. PubMed PMID: 22534274.
ITP
Neunert CE. Current management of immune thrombocytopenia. Hematology Am Soc Hematol Educ Program. 2013;2013:276-82. doi: 10.1182/asheducation-2013.1.276. Review. PubMed PMID: 24319191.
Lupus
Kiriakidou M, Cotton D, Taichman D, Williams S. Systemic lupus erythematosus. Ann Intern Med. 2013 Oct 1;159(7):ITC4-1. doi: 10.7326/0003-4819-159-7-201310010-01004. Review. PubMed PMID: 24081299.

May 29, 2018

Anticoagulation for patients high pretest probability of PE
Willoughby L, Adams DM, Evans RS, Lloyd JF, Stevens SM, Woller SC, Bledsoe JR, Aston VT, Wilson EL, Elliott CG. Preemptive Anticoagulation in Patients With a High Pretest Probability of Pulmonary Embolism: Are Guidelines Followed? Chest. 2018 May;153(5):1153-1159. doi: 10.1016/j.chest.2017.11.007. Epub 2017 Nov 15. PubMed PMID: 29154971.
Submassive PE
Rali PM, Criner GJ. Submassive Pulmonary Embolism. Am J Respir Crit Care Med. 2018 Apr 19. doi: 10.1164/rccm.201711-2302CI. [Epub ahead of print] PubMed PMID: 29672125.
ePrognosis
Calculator based on repository of published geriatric prognostic indices where clinicians can go to obtain evidence-based information on patients' prognosis.
Photonegative chest x-ray
Cherian SV, Thampy E. 'Photographic negative of pulmonary oedema': a classical radiographic pattern of chronic eosinophilic pneumonia. Postgrad Med J. 2015 Jul;91(1077):411-2. doi: 10.1136/postgradmedj-2015-133443. Epub 2015 Jul 8. PubMed PMID: 26155798.

May 17, 2017

ACC atrial fibrillation guideline
January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, Conti
JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW; ACC/AHA Task Force Members. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014 Dec 2;130(23):2071-104. doi: 10.1161/CIR.0000000000000040. Epub 2014 Mar 28. Erratum in: Circulation. 2014 Dec 2;130(23):e270-1. PubMed PMID: 24682348.
ACC focused update heart failure guideline
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH,
Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C. 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Am Coll Cardiol. 2017 Aug 8;70(6):776-803. doi: 10.1016/j.jacc.2017.04.025. Epub 2017 Apr 28. PubMed PMID: 28461007.
ACC focused update heart failure pharmacological therapy guideline
WRITING COMMITTEE MEMBERS, Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos G, Fonarow GC, Givertz MM, Hollenberg SM,
Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C. 2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2016 Sep 27;134(13):e282-93. doi: 10.1161/CIR.0000000000000435. Epub 2016 May 20. Erratum in: Circulation. 2016 Sep 27;134(13):e298. PubMed PMID: 27208050.
ACC 2013 heart failure guideline
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013 Oct 15;128(16):1810-52. doi: 10.1161/CIR.0b013e31829e8807. Epub 2013 Jun 5. PubMed PMID: 23741057.

May 15, 2018

IDSA rhinosinusitis guideline
Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER, File TM Jr; Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012 Apr;54(8):e72-e112. doi: 10.1093/cid/cir1043. Epub 2012 Mar 20. PubMed PMID: 22438350.
Approach to fever in returned traveller
Thwaites GE, Day NP. Approach to Fever in the Returning Traveler. N Engl J Med. 2017 Feb 9;376(6):548-560. doi: 10.1056/NEJMra1508435. Review. PubMed PMID: 28177860.
Measles in the returned traveller
Huang GK, Bond KA, Hewitt NH, Johnson PD. Measles: an important cause of fever and rash in a returned traveller. Med J Aust. 2014 Nov 17;201(10):605-6. PubMed PMID: 25390269.
Measles review
Moss WJ. Measles. Lancet. 2017 Dec 2;390(10111):2490-2502. doi: 10.1016/S0140-6736(17)31463-0. Epub 2017 Jun 30. Review. PubMed PMID: 28673424.
Risk of febrile seizure after measles-mumps-rubella-varicella vaccine
Ma SJ, Xiong YQ, Jiang LN, Chen Q. Risk of febrile seizure after measles-mumps-rubella-varicella vaccine: A systematic review and meta-analysis. Vaccine. 2015 Jul 17;33(31):3636-49. doi: 10.1016/j.vaccine.2015.06.009. Epub
2015 Jun 11. Review. PubMed PMID: 26073015.
Rate of MMR vaccination in U.S. (and vaccination in media)
Smith MJ, Ellenberg SS, Bell LM, Rubin DM. Media coverage of the measles-mumps-rubella vaccine and autism controversy and its relationship to MMR immunization rates in the United States. Pediatrics. 2008 Apr;121(4):e836-43. doi: 10.1542/peds.2007-1760. PubMed PMID: 18381512.

May 9, 2018

Unintentional weight loss
Wong CJ. Involuntary weight loss. Med Clin North Am. 2014 May;98(3):625-43. doi: 10.1016/j.mcna.2014.01.012. Epub 2014 Mar 21. Review. PubMed PMID: 24758965.
Unintentional weight loss in older adults
Gaddey HL, Holder K. Unintentional weight loss in older adults. Am Fam Physician. 2014 May 1;89(9):718-22. Review. PubMed PMID: 24784334.
Includes Meals on Wheels mnemonic
AHRQ ePSS app
The ePSS is an application designed to help primary care clinicians identify clinical preventive services that are appropriate for their patients. Use the tool to search and browse U.S. Preventive Services Task Force (USPSTF) recommendations on the web or on your PDA or mobile device.
Hyperthyroidism
De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet. 2016 Aug 27;388(10047):906-918. doi: 10.1016/S0140-6736(16)00278-6. Epub 2016 Mar 30. Review. PubMed PMID: 27038492; PubMed Central PMCID: PMC5014602.

May 8, 2018

Pleural effusion
Porcel JM, Light RW. Diagnostic approach to pleural effusion in adults. Am Fam Physician. 2006 Apr 1;73(7):1211-20. Review. PubMed PMID: 16623208.
CDC Travel: India
TB
Jacobson KR. Tuberculosis. Ann Intern Med. 2017 Feb 7;166(3):ITC17-ITC32. doi: 10.7326/AITC201702070. Review. PubMed PMID: 28166561.
Tuberculous pleural effusion
Zhai K, Lu Y, Shi HZ. Tuberculous pleural effusion. J Thorac Dis. 2016 Jul;8(7):E486-94. doi: 10.21037/jtd.2016.05.87. Review. PubMed PMID: 27499981; PubMed Central PMCID: PMC4958858.

May 2, 2018

Head injury
Mendelow AD, Timothy J, Steers JW, Lecky F, Yates D, Bouamra O, Woodford M, Hutchinson PJ. Management of patients with head injury. Lancet. 2008 Aug 23;372(9639):685-7. doi: 10.1016/S0140-6736(08)61280-5. Review. PubMed PMID: 18722872.
SIADH
Cuesta M, Thompson CJ. The syndrome of inappropriate antidiuresis (SIAD). Best Pract Res Clin Endocrinol Metab. 2016 Mar;30(2):175-87. doi: 10.1016/j.beem.2016.02.009. Epub 2016 Feb 27. Review. PubMed PMID: 27156757.
Hypothyroidism and Hyponatremia: Rather Coincidence Than Causality
Wolf P, Beiglböck H, Smaijs S, Wrba T, Rasoul-Rockenschaub S, Marculescu R,
Gessl A, Luger A, Winhofer Y, Krebs M. Hypothyroidism and Hyponatremia: Rather Coincidence Than Causality. Thyroid. 2017 May;27(5):611-615. doi: 10.1089/thy.2016.0597. Epub 2017 Apr 19. PubMed PMID: 28351291.
Hypothyroidism-associated hyponatremia: mechanisms, implications and treatment
Liamis G, Filippatos TD, Liontos A, Elisaf MS. MANAGEMENT OF ENDOCRINE DISEASE: Hypothyroidism-associated hyponatremia: mechanisms, implications and treatment. Eur J Endocrinol. 2017 Jan;176(1):R15-R20. Epub 2016 Aug 2. Review. PubMed PMID: 27484454.

May 1, 2018

Nausea
Scorza K, Williams A, Phillips JD, Shaw J. Evaluation of nausea and vomiting. Am Fam Physician. 2007 Jul 1;76(1):76-84. Review. PubMed PMID: 17668843.
D-Dimer
Weitz JI, Fredenburgh JC, Eikelboom JW. A Test in Context: D-Dimer. J Am Coll Cardiol. 2017 Nov 7;70(19):2411-2420. doi: 10.1016/j.jacc.2017.09.024. Review. PubMed PMID: 29096812.
Do patients with submassive pulmonary embolism benefit from thrombolytic therapy?
Ataya A, Cope J, Shahmohammadi A, Alnuaimat H. Do patients with submassive pulmonary embolism benefit from thrombolytic therapy? Cleve Clin J Med. 2016 Dec;83(12):923-932. doi: 10.3949/ccjm.83a.15116. Review. PubMed PMID: 27938515.
Post operative fever
Abdelmaseeh TA, Bhimji SS. Postoperative Fever. 2018 Jan 19. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK482299 PubMed PMID: 29493924.
Post operative fever
Includes Classic “Ws” of postoperative fever
Narayan M, Medinilla SP. Fever in the postoperative patient. Emerg Med Clin North Am. 2013 Nov;31(4):1045-58. doi: 10.1016/j.emc.2013.07.011. Review. PubMed PMID: 24176478.

April 25, 2018

Medical management of first trimester abortions
American College of Obstetricians and Gynecologists. Practice bulletin no. 143: medical management of first-trimester abortion. Obstet Gynecol. 2014 Mar;123(3):676-92. doi: 10.1097/01.AOG.0000444454.67279.7d. PubMed PMID: 24553166.
PNH
Parker CJ. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria. Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):208-216. Review. PubMed PMID: 27913482.
PNH
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep;95(3):190-8. doi: 10.1111/ejh.12543. Epub 2015 Mar 26. Review. PubMed PMID: 25753400.
PNH and pregnancy
Patel A, Unnikrishnan A, Murphy M, Egerman R, Wheeler S, Richards A, Wingard J. Paroxysmal Nocturnal Hemoglobinuria in Pregnancy: A Dilemma in Treatment and Thromboprophylaxis. Case Rep Hematol. 2017;2017:7289126. doi: 10.1155/2017/7289126. Epub 2017 Sep 24. PubMed PMID: 29147590; PubMed Central PMCID: PMC5632866.

April 24, 2018

Cannabinoid hyperemesis syndrome
Lu ML, Agito MD. Cannabinoid hyperemesis syndrome: Marijuana is both antiemetic and proemetic. Cleve Clin J Med. 2015 Jul;82(7):429-34. doi: 10.3949/ccjm.82a.14023. Review. PubMed PMID: 26185942.
Cerebellar stroke
Datar S, Rabinstein AA. Cerebellar infarction. Neurol Clin. 2014 Nov;32(4):979-91. doi: 10.1016/j.ncl.2014.07.007. Epub 2014 Sep 13. Review. PubMed PMID: 25439292.
Ischemic stroke
Hasan TF, Rabinstein AA, Middlebrooks EH, Haranhalli N, Silliman SL, Meschi JF, Tawk RG. Diagnosis and Management of Acute Ischemic Stroke. Mayo Clin Proc. 2018 Apr;93(4):523-538. doi: 10.1016/j.mayocp.2018.02.013. Review. PubMed PMID: 29622098.
tPA for ishemic stroke
Fugate JE, Rabinstein AA. Update on intravenous recombinant tissue plasminogen activator for acute ischemic stroke. Mayo Clin Proc. 2014 Jul;89(7):960-72. doi: 10.1016/j.mayocp.2014.03.001. Epub 2014 Apr 26. Review. PubMed PMID: 24775222.

April 16, 2018

Altered mental status in older patients
Han JH, Wilber ST. Altered mental status in older patients in the emergency department. Clin Geriatr Med. 2013 Feb;29(1):101-36. doi: 10.1016/j.cger.2012.09.005. Review. PubMed PMID: 23177603; PubMed Central PMCID: PMC3614410.
Evaluation of altered mental status
Wilber ST, Ondrejka JE. Altered Mental Status and Delirium. Emerg Med Clin North Am. 2016 Aug;34(3):649-65. doi: 10.1016/j.emc.2016.04.012. Review. PubMed PMID: 27475019.
Folate level related to altered mental status?
Castillo-Lancellotti C, Margozzini P, Valdivia G, Padilla O, Uauy R, Rozowski J, Tur JA. Serum folate, vitamin B12 and cognitive impairment in Chilean older adults. Public Health Nutr. 2015 Oct;18(14):2600-8. doi: 10.1017/S1368980014003206. Epub 2015 Jan 20. PubMed PMID: 25600049.
Thiamine deficiency
Liu D, Ke Z, Luo J. Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy. Mol Neurobiol . 2017 Sep;54(7):5440-5448. doi: 10.1007/s12035-016-0079-9. Epub 2016 Sep 5. Review. PubMed PMID: 27596507; PubMed Central PMCID: PMC5337452.
Korsakoff’s syndrome
Arts NJ, Walvoort SJ, Kessels RP. Korsakoff's syndrome: a critical review. Neuropsychiatry Dis Treat. 2017 Nov 27;13:2875-2890. doi: 10.2147/NDT.S130078. eCollection 2017. Review. PubMed PMID: 29225466; PubMed Central PMCID: PMC5708199.
Wernicke Syndrome
Ferri’s Clinical Advisor 2018

April 11, 2018

Supraventricular tachycardia
Link MS. Clinical practice. Evaluation and initial treatment of supraventricular tachycardia. N Engl J Med. 2012 Oct 11;367(15):1438-48. doi: 10.1056/NEJMcp1111259. Review. PubMed PMID: 23050527.
Pulmonary hypertension
Ataya A, Patel S, Cope J, Alnuaimat H. Pulmonary arterial hypertension and associated conditions. Dis Mon. 2016 Nov;62(11):379-402. doi: 10.1016/j.disamonth.2016.03.006. Epub 2016 Apr 12. Review. PubMed PMID: 27083316.
Acute Lower GI bleed
Gralnek IM, Neeman Z, Strate LL. Acute Lower Gastrointestinal Bleeding. N Engl J Med. 2017 Mar 16;376(11):1054-1063. doi: 10.1056/NEJMcp1603455. Review. PubMed PMID: 28296600.
Colon cancer
Brenner H, Kloor M, Pox CP. Colorectal cancer. Lancet. 2014 Apr 26;383(9927):1490-1502. doi: 10.1016/S0140-6736(13)61649-9. Epub 2013 Nov 11. Review. PubMed PMID: 24225001.

April 9, 2019

Hyponatremia
Henry DA. In The Clinic: Hyponatremia. Ann Intern Med. 2015 Aug 4;163(3):ITC1-19. doi: 10.7326/AITC201508040. Review. PubMed PMID: 26237763.
Cortisol - normal daily rhythm
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks From Endocrinology: Adult and Pediatric (7th ed)
Adrenal insufficiency
Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lancet. 2014 Jun 21;383(9935):2152-67. doi: 10.1016/S0140-6736(13)61684-0. Epub 2014 Feb 4. Review. PubMed PMID: 24503135.

April 4, 2018

Colon cancer
Brenner H, Kloor M, Pox CP. Colorectal cancer. Lancet. 2014 Apr 26;383(9927):1490-1502. doi: 10.1016/S0140-6736(13)61649-9. Epub 2013 Nov 11. Review. PubMed PMID: 24225001.
Information Resource: PDQ® Cancer Information Summaries
The PDQ cancer information summaries are comprehensive, evidence-based summaries on topics that cover adult and pediatric cancer treatment, supportive and palliative care, screening, prevention, genetics, and integrative, alternative, and complementary therapies. Most of the summaries are available in two different formats: health professional or patient.
Pancreatic cancer
Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016 Jul 2;388(10039):73-85. doi: 10.1016/S0140-6736(16)00141-0. Epub 2016 Jan 30. Review. PubMed PMID: 26830752.
Esophageal cancer
Short MW, Burgers KG, Fry VT. Esophageal Cancer. Am Fam Physician. 2017 Jan 1;95(1):22-28. PubMed PMID: 28075104.
Gastric cancer
Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H. Gastric cancer. Lancet. 2016 Nov 26;388(10060):2654-2664. doi: 10.1016/S0140-6736(16)30354-3. epub 2016 May 5. Review. PubMed PMID: 27156933.
Hepatocellular carcinoma
Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018 Jan 4. pii: S0140-6736(18)30010-2. doi: 10.1016/S0140 6736(18)30010-2. [Epub ahead of print] Review. PubMed PMID: 29307467.
Anal cancer
Simpson JA, Scholefield JH. Diagnosis and management of anal intraepithelial neoplasia and anal cancer. BMJ. 2011 Nov 4;343:d6818. doi: 10.1136/bmj.d6818. Review. PubMed PMID: 22058137.

April 3, 2018

Cholangiocarcinoma
Doherty B, Nambudiri VE, Palmer WC. Update on the Diagnosis and Treatment of Cholangiocarcinoma. Curr Gastroenterol Rep. 2017 Jan;19(1):2. doi: 10.1007/s11894-017-0542-4. Review. PubMed PMID: 28110453.
Cholangiocarcinoma - NCI treatment summary
PDQ Adult Treatment Editorial Board. Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®): Health Professional Version. 2018 Mar 14. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. Available from http://www.ncbi.nlm.nih.gov/books/NBK65869/ PubMed PMID: 26389308.
Hypothyroidism
Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Sep 23;390(10101):1550-1562. doi: 10.1016/S0140-6736(17)30703-1. Epub 2017 Mar 20. Review. PubMed PMID: 28336049.
Myxedema coma
Klubo-Gwiezdzinska J, Wartofsky L. Thyroid emergencies. Med Clin North Am. 2012 Mar;96(2):385-403. doi: 10.1016/j.mcna.2012.01.015. Epub 2012 Feb 17. Review. PubMed PMID: 22443982.
Pericardial effusion
Azarbal A, LeWinter MM. Pericardial Effusion. Cardiol Clin. 2017 Nov;35(4):515-524. doi: 10.1016/j.ccl.2017.07.005. Review. PubMed PMID: 29025543.
Pulsus paradoxus

March 19, 2018

Infectious Disease Prophylaxis in Solid Organ Transplantation
Personett HA, Laub MR. Review of Infectious Disease Prophylaxis in Solid Organ Transplantation. Crit Care Nurs Q. 2017 Oct/Dec;40(4):383-398. doi: 10.1097/CNQ.0000000000000175. Review. PubMed PMID: 28834860.
Histoplasmosis in transplant patients
Gajurel K, Dhakal R, Deresinski S. Histoplasmosis in transplant recipients. Clin Transplant. 2017 Oct;31(10). doi: 10.1111/ctr.13087. Epub 2017 Sep 5. Review. PubMed PMID: 28805270.
Histoplasmosis
Azar MM, Hage CA. Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. Clin Chest Med. 2017 Sep;38(3):403-415. doi: 10.1016/j.ccm.2017.04.004. Epub 2017 May 17. Review. PubMed PMID: 28797485.
Antifungal therapy - mechanisms
Scorzoni L, de Paula E Silva AC, Marcos CM, Assato PA, de Melo WC, de Oliveira HC, Costa-Orlandi CB, Mendes-Giannini MJ, Fusco-Almeida AM. Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis. Front Microbiol. 2017 Jan 23;8:36. doi: 10.3389/fmicb.2017.00036. eCollection 2017. Review. PubMed PMID: 28167935; PubMed Central PMCID: PMC5253656.

March 16, 2018

Recurrent fever
Knockaert DC. Recurrent fevers of unknown origin. Infect Dis Clin North Am. 2007 Dec;21(4):1189-211, xi. Review. PubMed PMID: 18061093.
Eosinophilia
Kovalszki A, Weller PF. Eosinophilia. Prim Care. 2016 Dec;43(4):607-617. doi: 10.1016/j.pop.2016.07.010. Epub 2016 Oct 14. Review. PubMed PMID: 27866580; PubMed Central PMCID: PMC5293177.
Strongyloides
Greaves D, Coggle S, Pollard C, Aliyu SH, Moore EM. Strongyloides stercoralis infection. BMJ. 2013 Jul 30;347:f4610. doi: 10.1136/bmj.f4610. Review. PubMed PMID: 23900531.
Evidence-Based Guidelines for Screening and Management of Strongyloidiasis in Non-Endemic Countries
Requena-Méndez A, Buonfrate D, Gomez-Junyent J, Zammarchi L, Bisoffi Z, Muñoz J. Evidence-Based Guidelines for Screening and Management of Strongyloidiasis in Non-Endemic Countries. Am J Trop Med Hyg. 2017 Sep;97(3):645-652. doi: 10.4269/ajtmh.16-0923. epub 2017 Jul 27. Review. PubMed PMID: 28749768.

March 12, 2018

Acute generalized weakness
Anderson, Robert S (02/2013). "Generalized weakness in the geriatric emergency department patient: an approach to initial management.". Clinics in geriatric medicine (0749-0690), 29 (1), 91.
Hyperglycemic hyperosmolar state
Stoner GD. Hyperosmolar Hyperglycemic State. Am Fam Physician. 2017 Dec 1;96(11):729-736. PubMed PMID: 29431405.
DKA
Wilson JF. In clinic. Diabetic ketoacidosis. Ann Intern Med. 2010 Jan 5;152(1):ITC1-1, ITC1-2, ITC1-3,ITC1-4, ITC1-5, ITC1-6, ITC1-7, ITC1-8, ITC1-9, ITC1-10, ITC1-11, ITC1-12, ITC1-13, ITC1-14, ITC1-15, table of contents; quiz ITC1-16. doi: 10.7326/0003-4819-152-1 201001050-01001. Review. PubMed PMID: 20048266.

March 7, 2018

CDC Travel information: India
Health Information for Travelers to India Clinician View
Fever in the returning traveller
Thwaites GE, Day NP. Approach to Fever in the Returning Traveler. N Engl J Med. 2017 Feb 9;376(6):548-560. doi: 10.1056/NEJMra1508435. Review. PubMed PMID: 28177860.
Rickettsial illnesses
Fang R, Blanton LS, Walker DH. Rickettsiae as Emerging Infectious Agents. Clin Lab Med. 2017 Jun;37(2):383-400. doi: 10.1016/j.cll.2017.01.009. Review. PubMed PMID: 28457356.
Enteric fever
Dave J, Sefton A. Enteric fever and its impact on returning travellers. Int Health. 2015 May;7(3):163-8. doi: 10.1093/inthealth/ihv018. Epub 2015 Mar 24. Review. PubMed PMID: 25808163.
Febrile agglutination test
“The nonspecific Weil-Felix febrile agglutination test, which detects IgM antibodies to a typhus cross-reactive LPS epitope found in Proteus OX19 antigen, is not used in the US but is sometimes employed in less developed countries. “ From Principles and Practice of Pediatric Infectious Diseases

March 6, 2018

Acute pancreatitis
Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981. Review. PubMed PMID: 27959604.
Cholangitis
Ahmed M. Acute cholangitis - an update. World J Gastrointest Pathophysiol. 2018 Feb 15;9(1):1-7. doi: 10.4291/wjgp.v9.i1.1. Review. PubMed PMID: 29487761; PubMed Central PMCID: PMC5823698.
Legionnaires’ Disease
Cunha BA, Burillo A, Bouza E. Legionnaires' disease. Lancet. 2016 Jan 23;387(10016):376-385. doi: 10.1016/S0140-6736(15)60078-2. Epub 2015 Jul 28. Review. PubMed PMID: 26231463.
Rhabdomyolysis
Torres PA, Helmstetter JA, Kaye AM, Kaye AD. Rhabdomyolysis: pathogenesis, diagnosis, and treatment. Ochsner J. 2015 Spring;15(1):58-69. Review. PubMed PMID: 25829882; PubMed Central PMCID: PMC4365849.
Legionella infections and rainfall in mid-Atlantic states
Hicks LA, Rose CE Jr, Fields BS, Drees ML, Engel JP, Jenkins PR, Rouse BS,
Blythe D, Khalifah AP, Feikin DR, Whitney CG. Increased rainfall is associated with increased risk for legionellosis. Epidemiol Infect. 2007 Jul;135(5):811-7. epub 2006 Nov 23. PubMed PMID: 17121693; PubMed Central PMCID: PMC2870637.

February 28, 2018

Hypopituiarism
Higham CE, Johannsson G, Shalet SM. Hypopituitarism. Lancet. 2016 Nov 12;388(10058):2403-2415. doi: 10.1016/S0140 6736(16)30053-8. Epub 2016 Mar 31. Review. PubMed PMID: 27041067.
Empty sella syndrome
Chiloiro S, Giampietro A, Bianchi A, Tartaglione T, Capobianco A, Anile C, De Marinis L. DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review. Eur J Endocrinol. 2017 Dec;177(6):R275-R285. doi: 10.1530/EJE-17-0505. Epub 2017 Aug 5. Review. PubMed PMID: 28780516.
Adrenal insufficiency
Pazderska A, Pearce SH. Adrenal insufficiency - recognition and management. Clin Med (Lond). 2017 Jun;17(3):258-262. doi: 10.7861/clinmedicine.17-3-258. Review. PubMed PMID: 28572228.
Hypothyroidism
Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Sep 23;390(10101):1550-1562. doi: 10.1016/S0140-6736(17)30703-1. Epub 2017 Mar 20. Review. PubMed PMID: 28336049.

February 26, 2018

Acetaminophen-induced hepatotoxicity
Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update. J Clin Transl Hepatol. 2016 Jun 28;4(2):131-42. doi: 10.14218/JCTH.2015.00052. Epub 2016 Jun 15. Review. PubMed
PMID: 27350943; PubMed Central PMCID: PMC4913076.
Acute liver failure
Singh T, Gupta N, Alkhouri N, Carey WD, Hanouneh IA. A guide to managing acute
liver failure. Cleve Clin J Med. 2016 Jun;83(6):453-62. doi:
10.3949/ccjm.83a.15101. Review. PubMed PMID: 27281258.

February 20, 2018

Hereditary angioedema
Tse K, Zuraw BL. Recognizing and managing hereditary angioedema. Cleve Clin J Med. 2013 May;80(5):297-308. doi: 10.3949/ccjm.80a.12073. Review. PubMed PMID: 23636922.
Acute management of hereditary angioedema
Katelaris CH. Acute Management of Hereditary Angioedema Attacks. Immunol
Allergy Clin North Am. 2017 Aug;37(3):541-556. doi: 10.1016/j.iac.2017.04.002.
Epub 2017 May 23. Review. PubMed PMID: 28687108.
Malaria prophylaxis for Rwanda
Centers for Disease Control & Prevention. (2018). Malaria Information and Prophylaxis, by Country. Available at https://www.cdc.gov/malaria/travelers/country_table/a.html
Addison Disease
Munir S, Waseem M. Addison Disease. 2017 Jun 24. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-. Available from http://www.ncbi.nlm.nih.gov/books/NBK441994/ PubMed PMID: 28723023.
Travelers Diarrhea
Steffen R, Hill DR, DuPont HL. Traveler's diarrhea: a clinical review. JAMA. 2015 Jan 6;313(1):71-80. doi: 10.1001/jama.2014.17006. Review. PubMed PMID: 25562268.

February 16, 2018

DVT
Spandorfer J, Galanis T. In the Clinic. Deep venous thrombosis. Ann Intern Med. 2015 May 5;162(9):ITC1. doi: 10.7326/AITC201505050. Review. PubMe PMID: 25939012.
Hypercoagulability screening
Connors JM. Thrombophilia Testing and Venous Thrombosis. N Engl J Med. 2017 Sep 21;377(12):1177-1187. doi: 10.1056/NEJMra1700365. Review. PubMed PMID: 28930509.
Antiphospholipid syndrome
Chaturvedi S, McCrae KR. Diagnosis and management of the antiphospholipid syndrome. Blood Rev. 2017 Nov;31(6):406-417. doi: 10.1016/j.blre.2017.07.006. Epub 2017 Jul 30. Review. PubMed PMID: 28784423; PubMed Central PMCID: PMC5714279.

February 14, 2018

Liver function tests
Agrawal S, Dhiman RK, Limdi JK. Evaluation of abnormal liver function tests. Postgrad Med J. 2016 Apr;92(1086):223-34. doi: 10.1136/postgradmedj-2015-133715. Epub 2016 Feb 3. Review. PubMed PMID: 26842972.
Cholestasis of sepsis
Bhogal HK, Sanyal AJ. The molecular pathogenesis of cholestasis in sepsis. Front Biosci (Elite Ed). 2013 Jan 1;5:87-96. Review. PubMed PMID: 23276972; PubMed Central PMCID: PMC4944118.
Melidiosis
Wiersinga WJ, Currie BJ, Peacock SJ. Melioidosis. N Engl J Med. 2012 Sep 13;367(11):1035-44. doi: 10.1056/NEJMra1204699. Review. PubMed PMID: 22970946
Legionnaire’s Disease
Cunha BA, Burillo A, Bouza E. Legionnaires' disease. Lancet. 2016 Jan 23;387(10016):376-385. doi: 10.1016/S0140 6736(15)60078-2. Epub 2015 Jul 28. Review. PubMed PMID: 26231463.
Pneumonia Caused by Legionella pneumophila
Chahin A, Opal SM. Severe Pneumonia Caused by Legionella pneumophila: Differential Diagnosis and Therapeutic Considerations. Infect Dis Clin North Am. 2017 Mar;31(1):111-121. doi: 10.1016/j.idc.2016.10.009. Review. PubMed PMID: 28159171.

February 7, 2018

Acute generalized weakness
Ganti L, Rastogi V. Acute Generalized Weakness. Emerg Med Clin North Am. 2016 Nov;34(4):795-809. doi: 10.1016/j.emc.2016.06.006. Epub 2016 Sep 3. Review. PubMed PMID: 27741989.
Hyponatremia
Henry DA. In The Clinic: Hyponatremia. Ann Intern Med. 2015 Aug 4;163(3):ITC1-19. doi: 10.7326/AITC201508040. Review. PubMed PMID: 26237763.
Mannitol as cause of hyponatremia?
- Hypotonic: osmotic diuresis (glucose, urea, mannitol)
- Hypertonic: hypertonic infusion (for example, glucose or mannitol)
- Isotonic: infrequently in cases involving absorption of large volumes of isotonic irrigant solution that do not contain sodium (for example 5% mannitol)
Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. 2000 May 25;342(21):1581-9. Review. PubMed PMID: 10824078.
SIADH
Esposito P, Piotti G, Bianzina S, Malul Y, Dal Canton A. The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options. Nephron Clin Pract. 2011;119(1):c62-73; discussion c73. doi: 10.1159/000324653. Epub 2011 Jun 15. Review. PubMed PMID: 21677440.
When to measure ACTH to differentiate primary and secondary adrenal insufficiency?
plasma adrenocorticotropic hormone (ACTH)
- useful for differentiating primary and secondary adrenal insufficiency
- measure waking plasma ACTH (usually 6 AM-9 AM)
- > 22 pmol/L (100 pg/mL) indicates primary adrenal insufficiency
- < 11 pmol/L (50 pg/mL) indicates secondary - adrenal insufficiency (ACTH levels may be undetectable in secondary adrenal insufficiency)
- elevated ACTH concentrations with normal cortisol concentrations may represent subclinical adrenal insufficiency that could progress

February 5, 2018

Acute scrotal pain
Srinath H. Acute scrotal pain. Aust Fam Physician. 2013 Nov;42(11):790-2. Review. PubMed PMID: 24217099.
RUQ pain
Avegno J, Carlisle M. Evaluating the Patient with Right Upper Quadrant Abdominal Pain. Emerg Med Clin North Am. 2016 May;34(2):211-28. doi: 10.1016/j.emc.2015.12.011. Review. PubMe PMID: 27133241.

Prehn Sign - Basis?
Prehn, D. T. (1934). A new sign in the differential diagnosis between torsion of the spermatic cord and epididymitis. The Journal of Urology, 32(2), 191-200.

Idiopathic retroperitoneal fibrosis
Vaglio A, Maritati F. Idiopathic Retroperitoneal Fibrosis. J Am Soc Nephrol. 2016 Jul;27(7):1880-9. doi: 10.1681/ASN.2015101110. Epub 2016 Feb 9. Review. PubMed PMID: 26860343; PubMed Central PMCID: PMC4926988.
Retroperitoneal fibrosis
Vaglio A, Salvarani C, Buzio C. Retroperitoneal fibrosis. Lancet. 2006 Jan 21;367(9506):241-51. Review. PubMed PMID: 16427494.

January 29, 2018

Falls - screening and prevention
Ambrose AF, Cruz L, Paul G. Falls and Fractures: A systematic approach to screening and prevention. Maturitas. 2015 Sep;82(1):85-93. doi: 10.1016/j.maturitas.2015.06.035. Epub 2015 Jun 26. Review. PubMed PMID: 26255681.
Community-acquired pneumonia
Niederman MS. In the Clinic: Community Acquired Pneumonia. Ann Intern Med. 2015 Oct 6;163(7):ITC1-17. doi: 10.7326/AITC201510060. Review. PubMed PMID: 26436631.
Streptococcus pneumoniae pneumonia - treatment
Per ISDA guidelines - recommendations for empiric treatment of community-acquired pneumonia in adult outpatients:
--For previously healthy persons with no antimicrobial use within past 3 month:
- macrolides (erythromycin, clarithromycin, azithromycin) as first-line treatment; doxycycline as second treatment option
--For patients with comorbidities, high risk of drug-resistant Streptococcus pneumoniae, or antibiotic use within past 3 months:
- respiratory fluoroquinolone - moxifloxacin, gemifloxacin, or levofloxacin 750 mg; macrolide (or doxycycline) plus beta-lactam is alternative first-line treatment

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Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, Torres A, Whitney CG; Infectious Diseases Society of America; American Thoracic Society. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72. PubMed PMID: 17278083.
Ciprofloxacin for
"For empirical outpatient therapy, guidelines from the Infectious Diseases Society of America and the American Thoracic Society 8 recommend a macrolide, doxycycline, a “respiratory” quinolone (levofloxacin or moxifloxacin, but not ciprofloxacin, which is thought to be slightly less effective against pneumococci), or a β-lactam together with a macrolide. These recommendations are based on a desire to provide therapy effective for common bacterial causes of pneumonia such as S. pneumoniae..."

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Musher, D.M. (2016). Overview of pneumonia. From Goldman-Cecil Medicine (25th ed.). Available at https://www.clinicalkey.com/#!/content/book/3-s2.0-B9781455750177000970

January 26, 2018

Severe asthma
Israel E, Reddel HK. Severe and Difficult-to-Treat Asthma in Adults. N Engl J Med. 2017 Sep 7;377(10):965-976. doi: 10.1056/NEJMra1608969. Review. PubMed PMID: 28877019.
Severe Asthma in Primary Care: Identification and Management
Trevor JL, Chipps BE. Severe Asthma in Primary Care: Identification and Management. Am J Med. 2018 Jan 16. pii: S0002-9343(18)30024-X. doi: 10.1016/j.amjmed.2017.12.034. [Epub ahead of print] Review. PubMed PMID: 29355509.
Global strategy for asthma management and prevention (2017 update)
Global Initiative for Asthma. (2017).Global strategy for asthma management and prevention (2017 update). Available at http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/
Asthma phenotypes
Hirose M, Horiguchi T. Asthma phenotypes. J Gen Fam Med. 2017 Aug 31;18(5):189-194. doi: 10.1002/jgf2.7. eCollection 2017 Oct. Review. PubMed PMID: 29264025; PubMed Central PMCID: PMC5689426.

January 22, 2018

Meningitis
Mount HR, Boyle SD. Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention. Am Fam Physician. 2017 Sep 1;96(5):314-322. PubMed PMID: 28925647.
Meningitis and encephalitis diagnostics
Hemmert AC, Gilbreath JJ. The current state of diagnostics for meningitis and encephalitis. MLO Med Lab Obs. 2016 Jul;48(7):12-4; quiz 16. Review. PubMed PMID: 27548918.
Herpes simplex encephalitis
Rabinstein AA. Herpes Virus Encephalitis in Adults: Current Knowledge and Old Myths. Neurol Clin. 2017 Nov;35(4):695-705. doi: 10.1016/j.ncl.2017.06.006. Epub 2017 Aug 10. Review. PubMed PMID: 28962808.
Brain abscess
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D. Brain abscess. N Engl J Med. 2014 Jul 31;371(5):447-56. doi: 10.1056/NEJMra1301635. Review. PubMed PMID: 25075836.

January 20, 2018

ISDA bacterial meningitis guideline
Tunkel, A. R., Hartman, B. J., Kaplan, S. L., Kaufman, B. A., Roos, K. L., Scheld, W. M., & Whitley, R. J. (2004). Practice guidelines for the management of bacterial meningitis. Clinical infectious diseases, 39(9), 1267-1284.
Indications for pneumococcal disease
Pallotta, A., & Rehm, S. J. (2016). Navigating pneumococcal vaccination in adults. Cleve Clin J Med, 83(6), 427-432.

January 16, 2018

Cholangiocarcinoma
Squadroni M, Tondulli L, Gatta G, Mosconi S, Beretta G, Labianca R. Cholangiocarcinoma. Crit Rev Oncol Hematol. 2017 Aug;116:11-31. doi: 10.1016/j.critrevonc.2016.11.012. Epub 2016 Nov 25. Review. PubMed PMID: 28693792.
Diverticulitis
Feuerstein JD, Falchuk KR. Diverticulosis and Diverticulitis. Mayo Clin Proc. 2016 Aug;91(8):1094-104. doi: 10.1016/j.mayocp.2016.03.012. Epub 2016 May 5. Review. PubMed PMID: 27156370.
Porcelain gallbladder
Revzin MV, Scoutt L, Smitaman E, Israel GM. The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdom Imaging. 2015 Feb;40(2):385-99. doi: 10.1007/s00261-014-0203-0. Review. PubMed PMID: 25063238.
Madura foot
Zijlstra EE, van de Sande WWJ, Welsh O, Mahgoub ES, Goodfellow M, Fahal AH. Mycetoma: a unique neglected tropical disease. Lancet Infect Dis. 2016 Jan;16(1):100-112. doi: 10.1016/S1473-3099(15)00359-X. Review. PubMed PMID: 26738840.
Mycetoma diagnosis
Ahmed AA, van de Sande W, Fahal AH. Mycetoma laboratory diagnosis: Review article. PLoS Negl Trop Dis. 2017 Aug 24;11(8):e0005638. doi: 10.1371/journal.pntd.0005638. eCollection 2017 Aug. Review. PubMed PMID: 28837657; PubMed Central PMCID: PMC5570215.
Mycetoma from Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
Chapter 263 from Agents of Mycetoma from Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (2015)